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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPHK2
All Species:
14.85
Human Site:
S484
Identified Species:
32.67
UniProt:
Q9NRA0
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRA0
NP_064511.2
654
69217
S484
S
P
K
A
A
L
H
S
P
V
S
E
G
A
P
Chimpanzee
Pan troglodytes
XP_001171276
652
69465
S482
S
P
K
A
A
L
H
S
P
V
S
E
G
A
P
Rhesus Macaque
Macaca mulatta
XP_001113908
653
69532
S483
S
P
K
T
A
L
H
S
P
V
T
E
G
A
P
Dog
Lupus familis
XP_541516
663
70246
S493
S
P
K
A
A
L
L
S
P
I
T
E
G
V
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9JIA7
617
65600
L448
N
A
L
K
T
A
Q
L
S
P
I
A
E
G
P
Rat
Rattus norvegicus
Q91V26
383
42400
L227
S
K
I
P
A
S
S
L
A
Q
K
G
P
A
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001088560
509
55981
E353
T
S
V
D
T
A
P
E
S
D
S
H
R
R
T
Zebra Danio
Brachydanio rerio
Q7ZW00
422
47526
D266
A
P
V
P
R
P
P
D
L
P
D
E
I
P
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647762
661
73852
S496
S
R
R
S
F
Y
Y
S
I
S
E
S
I
Y
H
Honey Bee
Apis mellifera
XP_394823
620
69588
T460
A
K
S
T
Y
F
S
T
G
S
I
S
S
Y
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LRB0
763
83573
N577
P
T
R
C
S
W
G
N
T
G
G
Q
D
R
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96
96.6
90.8
N.A.
78.4
26.6
N.A.
N.A.
N.A.
32.8
20.4
N.A.
32.2
29.3
N.A.
N.A.
Protein Similarity:
100
96.6
97.4
92.9
N.A.
84.2
37.9
N.A.
N.A.
N.A.
46.6
34
N.A.
46.4
45.7
N.A.
N.A.
P-Site Identity:
100
100
86.6
73.3
N.A.
6.6
20
N.A.
N.A.
N.A.
6.6
13.3
N.A.
13.3
0
N.A.
N.A.
P-Site Similarity:
100
100
93.3
86.6
N.A.
13.3
20
N.A.
N.A.
N.A.
13.3
20
N.A.
33.3
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
10
0
28
46
19
0
0
10
0
0
10
0
37
0
% A
% Cys:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
0
0
0
10
0
10
10
0
10
0
0
% D
% Glu:
0
0
0
0
0
0
0
10
0
0
10
46
10
0
10
% E
% Phe:
0
0
0
0
10
10
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
10
0
10
10
10
10
37
10
0
% G
% His:
0
0
0
0
0
0
28
0
0
0
0
10
0
0
19
% H
% Ile:
0
0
10
0
0
0
0
0
10
10
19
0
19
0
0
% I
% Lys:
0
19
37
10
0
0
0
0
0
0
10
0
0
0
0
% K
% Leu:
0
0
10
0
0
37
10
19
10
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
0
10
0
0
0
0
0
0
10
% N
% Pro:
10
46
0
19
0
10
19
0
37
19
0
0
10
10
46
% P
% Gln:
0
0
0
0
0
0
10
0
0
10
0
10
0
0
10
% Q
% Arg:
0
10
19
0
10
0
0
0
0
0
0
0
10
19
0
% R
% Ser:
55
10
10
10
10
10
19
46
19
19
28
19
10
0
0
% S
% Thr:
10
10
0
19
19
0
0
10
10
0
19
0
0
0
10
% T
% Val:
0
0
19
0
0
0
0
0
0
28
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
10
10
10
0
0
0
0
0
0
19
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _